Endocrine Abstracts

Purpose: To study the role of varying degrees of overweight in the course of menopause.

Materials and methods of the study: The study involved 278 women in the menopausal period aged 40 to 46 years, of which the main group (MG) consisted of 218 women with overweight and obesity of varying degrees. The control group (CG) included 60 women with normal body weight and a waist

Results of the study: As a result of the studies, we found that overweight (BMI - 25.0-29.9 kg/m2) was observed in 62 women (28.4%) out of 218 examined in the main group; in other cases, obesity of various severity (BMI - 30.0-41.2 kg/m2). 72.0% of overweight women noted an increase in BMI after 36 years, i.e. at the beginning of the late reproductive period, while women with obesity of varying severity after 40 years. In the CG, 33% of women from the CG noted weight gain after 36 years, although these indicators did not go beyond the normal range. Circumference of 80 cm. Women with overweight and obesity had a high comorbidity, so 36% of women from the MG had arterial hypertension, 22% had coronary heart disease, 10% had chronic venous insufficiency, and 10% of women noted arrhythmias. I would especially like to highlight the frequency of gastrointestinal diseases in women with OH, of which 42% is cholelithiasis, 62.4% is chronic gastritis, 18.3% is chronic colitis, 6% is peptic ulcer and 28.4% is chronic pancreatitis. The frequency of occurrence of gynecological pathology also depended on BMI, so in women with overweight in 58.4% of cases, uterine fibroids, adenomyosis, etc. were noted, while in the CG this percentage was 13.8%. The range of clinical symptoms in women with overweight, obesity and normal body weight differs, the former and the latter are dominated by headaches (in 95.0%), irritability (in 72.5%), sleep disturbance (in 67.5%), muscle and joint pain (in 62.5%), sexual dysfunction (in 52.5%). The climacteric syndrome in obese patients is more severe and often manifests with climacteric symptoms such as palpitations and tachycardia, excitability, dizziness, muscle and joint pain, hot flashes, and sexual dysfunction.

Conclusion: Thus, menopause is associated with an increased prevalence of overweight. Increased central fat deposition, reduced peripheral fat deposition, and ectopic fat accumulation contribute to cardiometabolic abnormalities, resulting in an increased prevalence of metabolic syndrome after menopause.