ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Women with preeclampsia show altered cortico- and sex steroid profiles
Olivia Trummer 1 , Christina Stern 2 , Sharmaine Reintar 1,3 , Veronika Tandl 1 , Karoline Mayer-Pickel 2 , Mila Cervar-Zivkovic 2 , Martin Fassnacht 4 , Max Kurlbaum 4 , Berthold Huppertz 5 , Herbert Fluhr 2 & Barbara Obermayer-Pietsch 1
1Medical University of Graz, Department of Internal Medicine, Graz, Austria; 2Medical University of Graz, Department of Obstetrics and Gynecology, Graz, Austria; 3CBmed, Center for Biomarker Research in Medicine, Graz, Austria; 4University Hospital Würzburg, Department of Internal Medicine I, Würzburg, Germany; 5Medical University of Graz, Gottfried Schatz Research Center, Division of Cell Biology, Histology and Embryology, Graz, Austria
Background: Preeclampsia (PE) is a complex condition of pregnancy, associated with substantial perinatal morbidity and mortality, affecting 2% to 8% of pregnancies worldwide. Its hallmarks are high blood pressure (hypertension) and endothelial dysfunction, leading to potential end-organ injury. Affected organ systems include liver, blood, kidneys, brain and placenta. In the present study, we investigated steroid hormones such as progestagens, estrogens, androgens, and glucocorticoids during pregnancy in order to describe maternal and fetal development. Aim of the present study was to compare steroid hormonal profiles throughout pregnancy between pregnant women, who develop preeclampsia and normotensive pregnant women.
Methods: Serum levels of 15 steroids were measured in 14 pregnant women with preeclampsia and 36 normotensive pregnant women by isotope-dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) at 8 different time points throughout pregnancy (12, 20, 24, 28, 32, 36 weeks of gestational age) as well as at delivery and 24h postpartum.
Results: Pregnant women with PE showed significantly higher mean levels of dehydroepiandrosterone (DHEA; P≤ 0.001), dehydroepiandrosterone sulfate (DHEAS; P≤ 0.001), testosterone (P≤0.001) as well as androstenedione (P≤0.001) and significantly lower mean levels of the cortisol/cortison ratio (P=0.001), 11-deoxycortisol (P=0.001), dihydrotestosterone (P≤0.001) and estradiol (P=0.024 throughout pregnancy compared to healthy controls.
Conclusion: PE status significantly altered serum steroid levels compared to normotensive pregnant women throughout pregnancy. A comparison of substrate-product ratios between women with PE and normotensive pregnant women may serve to derive new indices and candidate genes for steroid-metabolizing enzymes that should be further investigated as potential biomarkers for the prediction of PE.
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Endocrine Abstracts
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