Endocrine Abstracts

Aim: To study tne quality of life of children with primary hyperparathyroidism (PHPT).

Material and methods: 90 children with suspected PHPT were examined according to anamnesis, outpatient cards and surgical logs. The children were aged from 3 to 15 years old, who were treated in stationary conditions, and then were observed by us on an outpatient basis. 50 of them were treated surgically (1^st group), 40 (2^nd group) refused surgery for various reasons and received antiresorptive therapy. Complaints, objective, endocrinological condition of all patients were assessed. The preliminary diagnosis was made on the basis of the obtained clinical data, confirmed by laboratory and instrumental studies. To assess QoL, we used questionnaire of Pas and SF-36. The duration of the study ranged from 1-3-6 months to 1 year in the early postoperative period and 5-10-15 years in the long-term period.

Results: Quality of life indicators in patients with PHPT are significantly lower than in the control group, to a greater extent due to pain, general health, social functioning and vitality (P< 0.05). Thus, in patients with PHPT before surgery, a significant violation of both the physical and mental components of the quality of life was established. Further, in the 1st group of patients with surgical treatment, in dynamics after 3 and 6 months, all QoL indicators according to SF-36 were significantly closer to the control group in all domains. In the 2nd group of patients with conservative treatment in dynamics after 3, 6, 12 months and 10 years, all QoL indicators according to SF-36 remained significantly lower than the control group in all domains and did not change significantly. Thus, according to our studies of QoL in patients with PHPT of the compared groups, successful surgical treatment with normalization of the level of parathyroid metabolism contributes to a significant improvement in the quality of life of patients with PHPT of the 1st group already in the early stages after surgery and has a lasting effect in the long-term follow-up period.

Conclusions: The results obtained demonstrate the positive effect of surgical treatment from the patient’s point of view and confirm the feasibility of assessing the quality of life both at the decision-making stage when choosing a surgical approach and as part of a comprehensive assessment of the effectiveness of therapy in determining the degree of recovery of various aspects of functioning in patients after surgery.