Endocrine Abstracts

The objective is to assess the presence of possible correlation between the calculated body fat percentage (BFP) indicator and indicators of metabolic control in women of reproductive age with polycystic ovarian syndrome (PCOS).

Materials and Methods: The study included 80 women with a diagnosed PCOS according to the Rotterdam criteria. All study participants underwent standard general clinical studies with the determination of body mass index (BMI), waist circumference (WC) and laboratory tests (total cholesterol (TC), high density lipoproteins (HDL), non-HDcholesterol (non-HDcholesterol), glycated hemoglobin (Hb1c), C-peptide and insulin). The Visceral Obesity Index (VOI) and BFP were calculated. Mathematical analysis was carried out using the Statistica 10 program (StatSoft, USA). Differences were considered statistically significant at P< 0.05.

Results and Discussion: The results of the anthropometric study showed that the median BMI was 25.00 [20.00;29.50] kg/m2, the median WC was 85.00[69.00;90.00] cm, the median VOI was 0.79 [0.39; 1.46], BFP 30.35 [24.60 35.98]. Pro-inflammatory biomarkers were assessed, as median CRP was 0.83[0.44;2.12] mg/l, median fibrinogen was 3.70 [2.90;4.40]g/l. When assessing the state of lipid metabolism, it was found that the median values of blood lipid spectrum indicators were: TC 4.54[4.00; 4.92] mmol/l., HD1.57[1.28; 2.11] mmol/l, non-HDcholesterol 2.78[2.40; 3.52] mmol/l. Median Hb1c was 4.90[4.60;5.20] %, insulin 11.00[5.50;15.90]ng/ml, C-peptide 2.05[1.28; 2.84]ng/ml. Based on the results of the correlation analysis, a significant direct relationship was determined between the BFP and the VOI value (r=0.75; P< 0.05), WC (r=0.88; P< 0.05), insulin level (r=0, 56; P< 0.05), C-peptide level (r=0.59; P< 0.05), non-HDcholesterol value (r=0.60; P< 0.05), CRP level (r=0.78; P< 0.05). Correlation between BFP and the Hb1c level (r=0.09; P> 0.05), fibrinogen (r=0.45; P> 0.05) was not noted.

Conclusion: Estimated indicator of BFP is directly correlated with indicators of carbohydrate and fat metabolism in women of reproductive age with polycystic ovarian syndrome.