ECE2023 Eposter Presentations Reproductive and Developmental Endocrinology (48 abstracts)
Effects of Low-Carbohydrate Diet vs. Mediterranean Diet on Growth Factors in Women with PCOS: A Randomized Controlled Trial
Elena Vasukova 1 , Ekaterina Zaikova 2 , Olga Kalinina 2 , Inga Gorelova 3 , Irina Pyanova 1 , Elena Bogatyreva 3 , Elena Vasilieva 3 , Maria Kokina 2 , Elena Grineva 4 & Polina Popova 2
1Almazov National Medical Research Centre, Research Laboratory of Endocrine Diseases in Pregnancy, Institute of Endocrinology, Saint Petersburg, Russia; 2Almazov National Medical Research Centre, World-Class Research Center for Personalized Medicine, Saint Petersburg, Russia; 3Almazov National Medical Research Centre, Saint Petersburg, Russia; 4Almazov National Medical Research Centre, Endocrinology Institute, Saint Petersburg, Russia
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Ovarian fibrosis and altered angiogenesis have been discussed as important factors in the pathogenesis of PCOS. Lifestyle modification is the first step in the treatment of PCOS. However, a specific composition of diet that should be included in a lifestyle change program has not been determined.
The aim: Of the study was to compare the effects of low-carbohydrate diet (Low-Carb) and Mediterranean diet on the growth factors in women with PCOS.
Methods: 62 patients with PCOS were randomized into two groups according to the recommended diet: Low-Carb (n=32) and Mediterranean (n=30). The study protocol is described at clinicaltrials.gov (NCT05272657). Fasting serum samples were collected at baseline and after 3 months of dieting. Seven growth factors were analyzed in the serum employing Luminex®xMAP™ (Merck, Germany): epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), fms-related tyrosine kinase 3 ligand (FLT3L), platelet-derived growth factor AA (PDGF-AA), platelet-derived growth factor AB/BB (PDGF AB/BB), vascular endothelial growth factor a (VEGF-a) and transforming growth factor a (TGF-a).
Results: The Mediterranean diet decreased the levels of FLT3(medians before and after diet were 13.2 and 10.3 pg/ml respectively, P= 0.002), PDGF AA (5361 and 4660 pg/ml, P< 0.001), PDGF AA/BB (46328 and 44910 pg/ml, P=0.001), TGF-a (10.8 and 10.5 pg/ml, P=0.021) and VEGF-a (275 and 228 pg/ml, P=0.008). The low carbohydrate diet, on the contrary, increased the levels of FLT3(10.7 and 12.4 pg/ml, P< 0.001), PDGF AA/BB (47465 and 48404 pg/ml, P=0.005) and FGF 2 (59.4 and 60.7 pg/ml, P=0.007). When comparing the median changes between the two diets, the difference was significant for TGF-a (P=0.010), FLT3(P< 0.001), FGF2(P=0.001), PDGF AA and PDGF AA/BB (P< 0.001).
Conclusion: The Mediterranean diet reduced the levels of growth factors FLT3L, PDGF AA, PDGF AA/BB, TGF-a, VEGF-a, while the Low-Carb diet produced no changes in TGF-a, VEGF-a, EGF, PDGF AA and increased the levels of FLT3L, PDGF AA/BB and FGF 2.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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