Endocrine Abstracts

Butylparaben is an endocrine disrupting chemical (EDC) which is used as antimicrobial preservative in many cosmetic products. EDCs are structurally diverse class of synthetic and natural compounds. EDCs can cause non-communicable diseases such as obesity, type 2 diabetes, and neurodevelopmental disease. Present study investigated that whether exposure to butylparaben during maternal pregnancy could cause the offspring’s neuronal development disorder. In vitro study butyl paraben promoted apoptosis and inhibited proliferation of Sox1-GFP cell. The mRNA expressions for ER stress were evaluated. Furthermore, in vivo study for developmental neuro toxicity test battery for butylparaben was carried out. Butylparaben 100 mg/kg, 50 mg/kg was treated for pregnant mouse from E10.5 to weaning period. The result of behavior test shows abnormal cognitive, social and anxiety like behavior in butyl paraben treated mice. In vitro study, ER stress genes was evaluated, BiP, CHOP, and AFT6 were significantly up-regulated following treatment with EDC. From these results, butylparaben is a potential neuro developmental toxicant.