ECE2023 Eposter Presentations Adrenal and Cardiovascular Endocrinology (124 abstracts)
Pheochromocytomas: presentation and diagnosis
Sahar Abidi , Sabrine Mekni , Sawsen Essayeh , Cherchir Faten , Wafa Ben Hilel , Nadia Mchuirgui , Ibtissem Ben Nacef , Imen Rojbi & Karima Khiari
Charles Nicolles Hospital, Endocrinology Department, Tunis, Tunisia
Introduction: Pheochromocytomas are rare, mostly benign catecholamine-producing neuroendocrine tumors. Clinical manifestations are heterogenous, including persistent or paroxysmal hypertension, sweating, palpitation and headaches known as Menard triad. Diagnostic approach is based on demonstration of catecholamine excess and tumor localization. Our study aimed to describe clinico-biological and radiological features of pheochromocytomas.
Methods: We conducted a retrospective study including 34 patients with pheochromocytoma, who were admitted into the endocrinology department of Charles Nicolle hospital from 2005 to 2022. Data were extracted from medical records.
Results: The mean age at diagnosis was 48.1± 14.3 years [extremes:14-72] with a sex ratio (F/M) of 2.4. Hypertension, diabetes, coronary disease and chronic kidney disease were detected in 77, 27, 6 and 20% of cases, respectively. Screening for pheochromocytoma was motivated by adrenal incidentalomas, resistant hypertension, hypertension at a young age and Menard triad in 59, 12, 18 and 12% of cases, respectively. The median (IQR) metanephrine level was 200 (112.5-1369.5) μg/day and median (IQR) normetanephrine level was 1233.5 (565-5199.3) μg/day. On computed tomography, 53% of cases had a right adrenal tumor. Only one patient had bilateral tumors. Mean tumor size was 49.4±22.6 mm [extremes :10-100]. I-123 MIBG scintigraphy was performed in only nine patients with positive uptake.
Conclusion: Pheochromocytomas presentation is highly variable and can mimic other diseases. Because of cardiovascular complications, pheochromocytomas represent a potentially lethal condition, thus requiring early identification and management.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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