Endocrine Abstracts

Introduction: Prolactin adenomas are the most common pituitary adenomas. Although the pituitary increases in size and the prolactinoma increase gradually during normal pregnancy; prolactinomas do not contraindicate pregnancy but require strict monitoring.

Goals: To study the impact of pregnancy on the development of prolactin pituitary adenomas.

Materials and methods: Retrospective descriptive cohort study conducted in the endocrinology department of the CHU Ibnou Rochd Casablanca in pregnant patients followed for prolactin pituitary adenomas

Results: We report 7 pregnancies in 5 women, whose average age is 33 years: there is a single micro adenoma and 4 macro adenomas, 4 patients had thyrotropic insufficiency and 2 patients had corticotropic insufficiency. The average duration of evolution before pregnancy was 4 years and all our patients were treated with cabergoline with an average dose of 1.5 mg/week. When the pregnancy was discovered, only one patient stopped the treatment. A pituitary MRI was performed on 3 of our patients during pregnancy objectifying a quasi-stable appearance of the adenoma. Two patients were complicated by gestational diabetes. The pregnancies were carried to term, vaginally in 3 cases and cesarean section in 3 patients ; 3 patients breastfed with good clinical evolution.

Conclusion: The evolution of prolactinomas during pregnancy is variable. This may justify the continuation of dopaminergic agonist treatment during pregnancy, with close monitoring.