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Endocrine Abstracts (2023) 90 EP839 | DOI: 10.1530/endoabs.90.EP839

Burdenko Neurosurgery Center, Moskva, Russia


Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperative pe- riod. After release from the hospital, the patient independently stopped desmopressin therapy and did not consume an adequate amount of fluid of the background of polyuria. This led to severe hypernatremia (155–160 mmol/l) and rough mental disorders. Patients with ADI need closely monitoring of medical condition and water-electrolyte parameters, appointment of fixed doses of desmopressin and adequate hydration.

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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