Endocrine Abstracts

Introduction: Acromegaly is an unusual disease in adolescence. Its diagnosis and management are a challenge in this population. Here we report 2 rare cases of acromegaly in this age group.

Patients and Observations: Observation 1: This is a 17 year old patient admitted for acromegaly on pituitary microadenoma measuring 4*3mm who presents a symptomatology made of an accentuation of the growth rate, thin and long limbs, elongated hands and feet without dysmorphic syndrome and without tumor syndrome. His GH level is 1.8 times normal and IGF1normal. Therapeutically, the patient benefited from a total removal of the tumor.Observation 2: The patient was 16 years old and had been followed for acromegaly on pituitary macroadenoma since the age of 11 years. The initial symptomatology was an increase in growth rate without dysmorphic signs and without tumor syndrome. His IGF1 level was 2.3 times normal. The patient has already benefited from 3 surgeries of the adenoma with complementary medical treatment.

Conclusion: Adolescent Acromegaly is rare and characterized by large size and rapid progression of symptoms as the main diagnostic criteria. Other clinical signs are less marked than in adults. Surgery is the first-line treatment with importance of long-term follow-up.