ECE2023 Eposter Presentations Pituitary and Neuroendocrinology (234 abstracts)
Coexistence of PRL-secreting adenoma and germ cell tumor in 14-year-old adolescent
Alexey Kalinin 1 , Natalia Strebkova 1 , Igor Chugunov 1 , Galina Kolesnikova 1 , Olga Bezlepkina 1 , Olga Zheludkova 2 & Valentina Peterkova 1
1The National Medical Research Center for Endocrinology, Moscow, Russia; 2Scientific and Practical Center for Specialized Medical Care for Children named after V.F. Voyno-Yasenetsky, Moscow, Russia
Coexistence of different types of brain tumors is a very rare condition. We present a clinical case of PRL-secreting adenoma and germ cell tumor coexistence in 14-year-old adolescent. The patient was admitted to our Center with complaints of headache with nausea episodes, left-sided ptosis. Visual acuity was: visus OD=1.0; visus OS=0.6 Cyl -0.5 ax 70=1.0. Neuroimaging revealed supra-para(D,S) sellar mass 39×32×21 mm. Laboratory data revealed hypothyroidism, hypocortisolism and low prolactin level (43 mU/l). After 100-fold serum dilution (in order to exclude hook effect) prolactin level was 14 000 mU/l (n 60–510). Prolactinoma has been diagnosed and therapy with cabergoline (0.75 mg/week), hydrocortisone and levothyroxine was started. Two months after hospitalization visual acuity worsening has been noted and readmission was carried out. During second hospitalization, prolactin level became 4500 mU/l (after 100-fold serum dilution), MRI neuroimages showed a pronounced increase in the size of the neoplasm 78×52×48 mm. Levels of tumor markers were determined: hCG was <2.39 mIU/ml (n 0–2.39), AFP was >1000 IU/ml (n 0–5.5). Based on laboratory and instrumental data coexistence of PRL-secreting adenoma and AFP-secreting germ cell tumor was diagnosed. The patient was transferred to oncology department for immediate start of chemotherapy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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