ECE2023 Eposter Presentations Pituitary and Neuroendocrinology (234 abstracts)
Early postoperative growth hormone measurement as a predictor of surgical remission of acromegaly
Ivana Kraljevic 1,2 , Diana Kovač 3 , Mirsala Solak 1 , Tanja Skoric Polovina 1 , Karin Zibar Tomšić 1 , Annemarie Balasko 1 , Tina Dusek 1,2 & Darko Kastelan 1,2
1University Hospital Center Zagreb, Dpt od Endocrinology, Zagreb, Croatia; 2The University of Zagreb, School of Medicine, Zagreb, Croatia; 3County Emergency Medicine Institute, Dubrovnik, Croatia
Purpose: To evaluate the value of early postoperative growth hormone (GH) as a predictor of surgical remission of acromegaly.
Methods: We conducted a retrospective search through our database of patients who underwent transsphenoidal surgery for GH-secreting pituitary adenoma from 2011 to June 2022. Only patients who underwent the first pituitary surgery and had GH measurements on the fifth postoperative day were included. The surgical remission was defined as GH nadir <0.4 μg/l during an oral glucose tolerance test (OGTT) and normal insulin growth factor-1 (IGF-1) on the first follow-up three months after the surgery.
Results: We included 65 patients in the analysis with median FU of 31.5(3–155) months. Surgical remission was achieved in 44 patients (67.7%). Patients who achieved remission had significantly lower early postoperative GH levels (0.65 (0.06–8.92) vs. 3.61 (0.25–24.64), P<0.001). ROC analysis revealed a significant value of early postoperative GH on the prediction of surgical remission (AUC 0.832, P<0.0001), and the cut of GH≤1.57 μg/l had a sensitivity of 90.9% and a specificity of 71.4%, respectively. No patients with an early postoperative GH ≤0.23 μg/l developed a relapse of acromegaly during the FU.
Conclusion: The early postoperative growth hormone measurement could be a reliable predictor of surgical and long-term remission of acromegaly.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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