Endocrine Abstracts

Liver neuroendocrine carcinoma is a relatively rare disease. There is lack of description due to prognostic information of the disease. Liver serves as an visceral organ, taking part in several endocrine functions, according to an investigations has produced specific proteins and activate thyroid hormones, glucocorticoids. This article describes clinical case of 54 years man with clinical diagnosis of Grave’s disease. Liver examination showed normal liver hormones, radiology investigation revealed a nodule (size of the nodule 7.0–5.6 cm) localization in the right lobe of liver. Patient has no diagnosis of Hepatitis C virus, AFP was in normal range. According to liver postsurgical investigation the low Grade neuroendocrine carcinoma revealed. There are extremely rare cases of primary liver neuroendocrine carcinoma. Following our recommendations patient examined due to excluded metastatic lesions (colonoscopy procedure) and was revealed without tendency of cancer in the intestines. According to immune profile and histological examination neuroendocrine liver carcinoma Grade 1 revealed. Patient followed with thyroidectomy a year later with diagnosis of papillary thyroid microcarcinoma with multi centric growth and tendency in pre- and paratracheal lymph nodules (2 nodules). According to the literature, liver neuroendocrine carcinoma – Grade 1 don’t characterized with aggressive behavior. Therefore in such case, liver neuroendocrine carcinoma metastasis developed in the retroperitoneum after thyroidectomy, three months later. Neuroendocrine liver cancer is more aggressive in association with papillary thyroid cancer. As a conclusion there are rare cases of primary multiple carcinomas associated with papillary thyroid microcarcinoma in the literature, and this article is an example of aggressive follow up of Primary Multiple Carcinomas: liver neuroendocrine cancer with association of Papillary Thyroid Cancer.