ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
The association of cortisol secretion and body weight in overweight and obese patients
Angelika Buczyńska 1 , Katarzyna Łuka 2 , Ewa Duraj 3 , Maria Kościuszko 2 , Paweł Mierzejewski 2 , Aleksandra Wiatr 1 , Agnieszka Adamska 2 , Katarzyna Siewko 2 , Adam Krętowski 1,2 & Anna Popławska-Kita 2
1Medical University of Bialystok, Clinical Research Centre, Bialystok, Poland; 2Medical University of Bialystok, Department of Endocrinology, Diabetology and Internal Medicine, Bialystok, Poland; 3Medical University of Bialystok, Department of Periodontal and Oral Mucosa Diseases, Bialystok, Poland
Recently, 59 percent of European adults was diagnosed with obesity or overweight according to the 2022 Regional Obesity Report presented by the World Health Organization (WHO). Thus, insight into factors implicated in overweight and obesity may have important therapeutic implications. Interestingly, increased cortisol secretion and psychosocial stress have been demonstrated to be related with body weight-dependent insulin resistance and beta cells failure. Thus, the study was performed to assess the association of cortisol secretion, insulin resistance, and pancreatic beta cell failure occurrence. For the purpose of this study, 200 overweight and obese subjects (BMI>25 kg/m2) and 50 healthy volunteers (BMI<25 kg/m2) were enrolled. Study population was divided according to BMI values (into overweight (O1; BMI>25 kg/m2) and obesity (O2; BM>30 kg/m2)), homeostatic model assessment (HOMA) for insulin resistance (HOMA-IR) results (cut of 2). Simultaneously, among O1 and O2 study groups, the beta-cell function was assessed, and patients with pancreatic beta cell failure were appointed following HOMA estimates steady state beta cell function (HOMA-B) levels. The cortisol and adrenocorticotropic hormone (ACTH) concentrations were determined at Cobas E411 Roche device. The HOMA-IR and HOMA-B values were increased among O1 and O2 study groups comparing to control group (P<0.05, all). The cortisol concentration was increased in O2 comparing to control group (P<0.001). There were no differences in cortisol secretion in the O1 and control group. Nevertheless, comparing result obtained from patients among O1 and O2 groups with insulin resistance, the O1 patients were characterized with higher cortisol concentrations (P<0.03). Moreover, similar result was obtained among O1 and O2 patients characterized by pancreatic beta cell failure occurrence, where O1 patients were observed with increased cortisol secretion (P<0.05). The studied groups did not differ in ACTH concentrations. Based on the presented results, it can be assumed that obesity combined with insulin resistance or pancreatic beta cell insufficiency is associated with increased cortisol secretion.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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