Endocrine Abstracts

Metabolic syndrome (MS) is an actual problem of modern medicine. It is known that the prevalence of MS varies depending on the criteria used to determine it. It should be noted that the main criterion for MS is the central (abdominal) type of obesity. It is necessary to adapt the existing diagnostic criteria for MS in Russia, because it is necessary to take into account ethnic and genetic differences, national nutritional characteristics in the Russian population, lifestyle and economic opportunities. The purpose of the study: to evaluate the biochemical parameters and criteria for the metabolic syndrome.

Materials and methods: The study included 76 MS patients and 41 apparently healthy volunteers. The glucose level was determined by the glucose oxidant method, the lipid profile was assessed, and standard test systems were used. Insulin was determined by enzyme immunoassay using the DRG test system. All study participants signed an informed consent approved by the ethics committee. Statistical data processing was carried out using the application packages “Statistica for Windows 8.0”.

Results: The results obtained show an increase in insulin resistance index (HOMA-IR) values with an increase in glucose or fasting insulin levels. This coefficient is of the greatest diagnostic value and has received wide practical application. The calculation of HOMA-IR revealed an almost 2-fold increase in this indicator in patients with MS (P<0.05), which is a predictor of the risk of developing vascular and diabetic complications. The level of NEFA in patients with MS was increased in 95% of cases and was almost 2 times higher than the norm. Also, in patients with MS, there was an increase in the level of insulin and glucose in the blood in comparison with the control group (P<0.05).

Conclusion: The study shows that early diagnosis of MS is important for providing timely medical care and lifestyle correction (weight loss, dietary changes, regular physical activity) and preventing the development of severe vascular and diabetic complications.