ECE2023 Eposter Presentations Adrenal and Cardiovascular Endocrinology (124 abstracts)
Effect of long-term atorvastatin treatment on serum vitamin D levels in type 2 diabetes patients
Ameni Terzi 1 , Elyes Kamoun 1 , Meriem Yazidi 1 , Hammami Bassem 2 , Nadia Khessairi 1 , Ibtissem Oueslati 1 , Fatma Chaker 1 , Feki Moncef 2 & Melika Chihaoui 1
1Rabta, Endocrinology, Tunisia; 2Rabta, Biochemistry, Tunisia
Introduction: Statins are widely used in primary and secondary prevention of atherosclerotic cardiovascular diseases. The effects of statins on vitamin D are unclear. The reduction of cholesterol synthesis, a substrate for vitamin D synthesis and the decrease of LDL, the major carrier of vitamin D in the blood, can affect vitamin D metabolism. We aimed to evaluate the effect of high dose statin therapy on serum vitamin D levels.
Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin treatment was indicated. The patients had two visits, before and six months after the daily intake of 40 mg of atorvastatin. During each visit, they underwent a clinical examination and a fasting blood sample was collected for biological and hormonal measurements including parathormone and vitamin D.
Results: The median age was 58 years (IQR: 52-62). Twenty-seven (45%) were obese. Thirty-one patients (52%) had hypertension. Twenty percent of participants were on metformin, 12% on insulin, and 3% on sulfonylureas. The median of LDL-cholesterol decreased significantly after statin intake from 1.1g/l (IQR: 0.9-1.4) to 0.6 g/l (IQR: 0.5-0.7), P<10−3. Before statin administration, the median of corrected calcemia, phosphoremia and parathyroid hormone were respectively 2.3 mmol/l (IQR: 2.3-2.4), 1 mmol/l (IQR: 0.9-1), and 6.6 pmol/l (IQR: 4.9-10.2) and did not change significantly after statin intake. The median level of vitamin D was 37.4 nmol/l (IQR: 26.1–52.7) before atorvastatin therapy and 40.5 nmol/l (IQR: 26.3–56.1) after statin intake (P=0.828).
Conclusion: Long-term high dose atorvastatin treatment in patients with type 2 diabetes mellitus did not affect serum vitamin D levels and calcium homeostasis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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