ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Can prebiotics improve daytime sleepiness in obese patients?
Rym Ben Othman , Zeineb Zemni , Chaima El Ghali , Berriche Olfa , Ramla Mizouri , Wafa Douiri , Nadia Ben Amor , Faten Mahjoub & Jamoussi Henda
National Institute of Nutrition of Tunis, Obesity Research Unit, Bab Saadoun, Tunis, Tunisia.
Background: Excessive daytime sleepiness is a common complaint in obese patients affecting life quality. The objective of our work was to evaluate the impact of prebiotics intake on daytime sleepiness in addition to a weight loss program.
Methods: This is an interventional study involving 30 obese patients consulting the obesity unit of the Institute of Nutrition of Tunis during the period from May to August 2022. Patients were divided into 2 groups matched for age, sex and BMI: diet alone and prebiotics (30 g of carob/d). No patients took antibiotics during the intervention period and no patient stopped taking carob. Daytime sleepiness was assessed at T0 and at one month after the intervention (T1) using the Epworth sleepiness scale. A score ≥ 10 indicates excessive daytime sleepiness (EDS). The statistical level of significance was defined as P<0.05.
Results: The mean age was 40.3±6.7 years with a female predominance (80% of women). EDS was found in 46.7% patients in each group at T0. There was a significant weight loss in each group (diet only group: −2.5 kg P=0.001 and prebiotic group: −2.2 kg, P=0.003). However, there was no statistically significant difference in weight loss between the two groups (P=0.7). For the diet alone group there was an improvement in the Epworth score between T0 and T1 that was not statistically significant (9.8 vs 8. 6, P=0.06). For the prebiotic group, we have noticed a statistically significant decrease in Epworth score (8.7 vs 7, P=0.02) however, when comparing both groups, the difference was not significant (P=0.06).
Conclusion: It seems that prebiotics improve excessive daytime sleepiness in obese patients. Further studies are needed to understand the underlying mechanisms.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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