Endocrine Abstracts

COVID-19 significantly influenced global mortality; it caused 6.6 million cases of death. Mortality or crude death rate (CDR) is a typical statistical value for analyzing the demographic processes among the population. In Ukraine, we observed an increase in CDR in 2020-2021. It could be caused directly by the COVID-19 pandemic and indirectly; due to social distancing. Some people avoid visiting a doctor and neglect their treatment of chronic diseases. Comorbidities such as obesity could lead to the rapid progression of COVID-19, especially in the presence of a ‘deadly triad’ (Lim S. et al., 2020) as age, male gender, and access to adiposity in the body). We decided to check the influence of obesity on the outcome of COVID-19 hospitalization. The research aimed to find the correlation between BMI and laboratory findings such as C-reactive protein and interleukin-6. We researched inpatients with COVID-19 and metabolic disorders to determine whether obesity influenced the inflammatory process and caused poor outcomes with a high probability of acute respiratory distress syndrome; the obtained data from the performed research approved that hypothesis. We analyzed 130 cases of hospitalization due to COVID-19 in the Medical Centre Universal Clinic “Oberig” in 2020-2021. We compared the group of inpatient survivors (n=90) and non-survivals (n=42). The mean age was 81 years (CI 78-84) and 79 years (CI 70-81), correspondingly (P<0.001). In previous studies, we found that the frequency of obesity raised to. We compared several parameters, such as the minimal absolute lymphocytes count that was observed during hospitalization (0.56 (0.4-0.9) and 0.19 (0.1-0.28), P<0.001); the highest C-reactive protein (CRP) (37.57(17.06-72.97) and 120.98 (75.21-179.6), P<0.001); baseline IL-6 (23.5 (9.1-43.4) and 33.4 (17.7-74.9), P=0.008); baseline ferritin (328 (154-558) 735 (415.5-1175), P<0.001). Mean Hb1Ac was 5.26% (4.78-5.87) and 5.5 (4.98-6.52), P=0.089). According to the received data, we calculated the correlation between BMI and the highest CRP (Ro=0.512), P=0.01.); between BMI and baseline IL-6 (Ro=0.686, P<0.01); between severity of respiratory insufficiency and minimal lymphocyte count (Ro=-0.598, P<0.01).

Conclusion: the paper is devoted to solving a significant scientific and practical problem of individual assessment of COVID-inpatients on the presence in them of high inflammatory rates, especially in the case of diabetes and obesity comorbidity as it could influence mortality and could be associated with poor prognosis.

Keywords: metabolic disorders, obesity, aging, IL-6, COVID-19, pandemic, public health, risk factors.