Endocrine Abstracts

Introduction: Metabolic syndrome (MetS) is combined groups of diseases with common pathogenesis and clinical signs and symptoms. Usually MS starts with obesity and last step appeared as a Diabetes Mellitus. We aimed to compare clinical signs and patients complaints according to type of manifestation of MetS.

Material and Methods: Patients data, clinical complaints, anthropometric, biochemical parameters in 248 patients with various manifestations of the MetS, such as obesity, impaired glucose tolerance (IGT), polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (DM2).

Results: The age of patients was important as a risk factor for the development of various manifestations of MetS. In particular, patients with PCOS were the youngest, and in the direction of obesity, IGT and DM2 the age were getting older. The BMI was higher in all patients with MetS, which indicated higher body weight in all groups. In particular, BMI was highest in obesity group (42.83 kg/m²), followed by IGT (36 kg/m²), PCOS (34.6 kg/m²), DM2 (32.34 kg/m²). Analysis of patients’ complaints made it possible to identify those that specific for manifestation forms of MetS. In particular, for DM2 the presence of dry mouse, thirst, frequent urination, weakness, dry skin were specific, whereas excessive food intake, weight gain, dyspnea were shown in IGT and obesity, excessive skin hairiness, infertility, menstrual cycle irregularities are more pronounced in PCOS, that could facilitate the identification and differential diagnosis of type of MetS manifestation in overweight or obese individuals in medical practice.

Conclusion: People age was main risk factors in the development of MetS where patients with PCOS were younger and getting older in direction to Obesity, then IGT and DM2. Comparing of BMI showed that it was higher in Obesity group and lowered into direction of IGT, PCOS then DM2. Comparison of people complaints revealed specific for various manifestation of MetS that will help in identification of type of MetS in people with obesity.