Endocrine Abstracts

Introduction: Non-diabetic hypoglycemia (NDH) is defined by a glycemia <0.50 g/l with the presence of neuroglycopenic signs and their disappearance after glucose administration.

Objective of the Study: Describe the diagnostic and therapeutic aspects of severe NDH cases in our department.

Material and Methods: Over a period of 12 years (2010 – 2022), 32 patients met the definition criteria.

Results: The average age of our patients was 48.4 years, with a female predominance (76.3%). Hypoglycemia was recurrent in 81% of cases with an average capillary blood sugar of 0.32 g/l occurring in a fasting state in 67% of patients and in post-prandial in 33% of cases. The fasting test carried out in 24 patients, with an average duration of 15.2 hours, pointed to an organic cause in 65% of cases with complementary imaging: pancreatic CT (34.1%), abdominal MRI (25%), CT angiography (6.7%), echo-endoscopy (28%), chest CT (3.1%) and pituitary MRI (3.1%). The different etiologies found were: an insulinoma (14, malignant in 2 cases), factitious hypoglycemia (6), an extrapancreatic tumor secreting IGF2 (4), functional hypoglycemia (6), nesidioblastosis (1) and corticotropic insufficiency (1).

Discussion: These results summarise the severity of NDH with female predominance.