Endocrine Abstracts

Introduction: Renin angiotensin system play a crucial role in the development of Diabetes Mellitus and its complications. According many studies, plasma renin level increased at the DM. However, mechanisms of its elevation is not clear yet. The aim of our study was compare plasma renin level in DM1 and DM2 patients and its relationship with glycemic control.

Material and Methods: In 44 people with DM1 and 85 with DM2 whose admitted into Hospital of the Republican Specialised Scientific Practical Medical Centre Endocrinology were collected clinical and anamnestic data, hemodynamic status, blood glycemia, HbA1c, and blood plasma renin activity were measured using immunoassay.

Results: Patients average age were significantly differ by type 19.0±2.33 and 58.17±1.17 y.o. DM duration were 2.51±0.94 and 8.74±0.93 years in DM1 and DM2 groups respectively. HbA1c level were 10.7±0.38% in DM1 and 8.86±0.27% in DM2 patients. Plasma renin activity were significantly higher than in healthy people in both group and was in 1.2 times higher in DM2 group. Interestingly, Plasma renin activity shown correlation with age, urine protein, also with FIB4 score in patients with DM1 but no any correlation found in DM2 group. Thus, results suggested about different mechanisms of elevation of plasma renin activity in DM1 and DM2.

Conclusion: Plasma renin activity significantly increased in both DM1 and DM2 groups, and suggested about high activity of RAAS. Plasma renin activity shown correlation with age, urine protein level in DM1 group, but not in DM2 and proposed about different mechanisms of its elevation depending of type.