ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Does prebiotics consumption improve glycemic parameters in obese adults?
Rym Ben Othman , Zeineb Zemni , Chaima El Ghali , Awatef Kacem , Wafa Douiri , Berriche Olfa , Ramla Mizouri , Nadia Ben Amor , Faten Mahjoub & Jamoussi Henda
National Institute of Nutrition of Tunis, Obesity Research Unit, Bab Saadoun, Tunis, Tunisia
Background: Alteration of gut microbiota leads to increased intestinal permeability, inflammation, and metabolic disorders. The aim of our study was to determine the effect of prebiotic supplementation on glycemic parameters in addition to a weight loss program.
Methods: This is an interventional study including 30 obese patients consulting the obesity unit of the Institute of Nutrition in Tunis. The patients were divided into 2 groups matched for age, sex and BMI: diet alone and prebiotics (30g of carob/day). Glycemic parameters (fasting blood glucose, HbA1c, fasting insulin levels and HOMA index= insulin resistance score) were assessed at T0 and at one month after the intervention (T1).
Results: The mean age was 40.3 ±6.7years with sex ratio Male/Female =0.25. Diabetes was found in 6.7% of patients in the diet alone group and 26.7% of patients in the prebiotic group (the difference between the two groups was not significant P=0.3). There was no significant difference between the two groups for glycemic parameters at T0 (fasting blood glucose, HbA1c, fasting insulin levels and HOMA index). For the diet alone group, there was a significant decrease in HbA1c between T0 and T1 (P=0.03). For the prebiotic group, we found a significant decrease in insulin levels (P=0.002) and insulin resistance score (P=0.009). A statistically significant difference between the diet alone group and the prebiotic group was found for the decrease in fasting blood glucose (0.01), insulin levels (P=0.03) and insulin resistance score (P= 0.01).
Conclusion: Prebiotics are superior to diet alone in improving the glycemic profile. Thus, they therefore have their place in the therapeutic arsenal of pre-diabetes and diabetes in obese patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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