Endocrine Abstracts

Objective: To determine the prevalence and analyze the predictive value of erectile dysfunction (ED) in the occurrence of fictional disorders (MD) in men with diabetes mellitus (DM).

Patients and Methods: Cross-sectional study of 90 men presenting with DM. A comparative analysis was performed between two subgroups: G1 (n=75) with MD vs G2 (n=15) without MD.

Results: G1 patients were older than G2 (59.7±10.3 vs 58±12 years). The duration of diabetes was significantly longer in G1 (11.9 vs 7.7 years; P=0.03). G1 had poorer glycaemic control than G2, as the mean HbA1C was statistically more impaired in G1 (9.5% vs 8%; P=0.01). Microvascular complications were more frequent in G1 (P=0.021), notably diabetic retinopathy (P=0.07), diabetic nephropathy (P=0.02), and peripheral neuropathy (P=0.000). Diabetic macroangiopathy was not associated with urinary disorders (P=0.07). There was a significantly higher prevalence of ED in G1 (23.3%) compared to G2 (7.5%); P=0.021. Multi-variate logistic regression confirmed that ED was an independent predictor of MD in men with DM with an Odds Ratio of 3.61 (P=0.005; 95% CI=[0.95-13.74]). Discussion: ED and MD are two manifestations of diabetic dysautonomia secondary to alteration of the autonomic nervous system and bladder-sphincter dyssynergia. ED, an earlier condition, should prompt the clinician to screen for and treat possible underlying urinary disorders.

References: 1. Guiming, Liu, and Daneshgari Firouz. "Diabetic bladder dysfunction." Chinese medical journal 127.07 (2014): 1357-1364.

2. Thorve, Vrushali S., et al. "Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management." Journal of diabetes and its complications 25.2 (2011): 129-136.