ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Gamma-GT blood levels and chronic complications of type 2 diabetes
Eya Safi , Ramla Mizouri , Ben Ali Khaoula , Zeineb Zemni , Imen Ouderni , Emna Bornaz , Nadia Ben Amor , Rym Ben Othman , Berriche Olfa , Faten Mahjoub & Jamoussi Henda
National Institute of Nutrition, A, Tunis, Tunisia
Objective: Our objective was to determine the relationship between mean blood gamma-GT (GGT) levels and chronic complications of type 2 diabetes.
Patients and Methods: This was a descriptive study including 89 diabetic patients followed at the department A of the National Institute of Nutrition in Tunis.
Results: The mean age was 56.44 ±13.02 years. The mean GGT level was 54.77±61.13 IU/l. Diabetes was uncontrolled in 93% of cases with a mean HbA1C of 10.7%. Diabetic retinopathy, nephropathy, and neuropathy were noted in 43%, 19%, and 26% of cases, respectively. Macroangiopathic complications were dominated by coronary artery disease (17%). The analytical study showed a statistically significant association between plasma GGT concentration and the presence of diabetic retinopathy (P=0.026). Plasma GGT concentration was also higher in nephropathy and neuropathy (P=0.13 and P=0.15 respectively) but not significantly. Coronary and arterial patients had higher mean GGT (P=0.43 and P=0.4 respectively). The same was true for patients with a history of stroke, and significantly so (P=0.017).
Discussion: GGT would induce an increase in oxidative stress and lipid accumulation in hepatocytes, thus leading to insulin resistance in hepatocytes1. It would therefore be a possible biomarker for the detection of diabetic complications.
Reference: 1. Gasecka A et al. Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes. J Clin Med.2020.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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