Endocrine Abstracts

Some patients with type 2 diabetes mellitus (T2DM) suffer from severe insulin resistance (IR). There is still a shortage of research analyzing these patients. Relation between IR and diabetes complications, risk of mortality has been poorly described in patients with T2DM.

Objective: To evaluate the prevalence of microvascular and macrovascular complications, mortality in type 2 diabetes patients with severe insulin resistance.

Methods: It was a case control study. If T2DM patients received high insulin doses (>1 IU/kg/day) and their HbA1c ≥9%, they were assigned to the case group (n=58). Patients with lower insulin requirements (<1 IU/kg/day) and HbA1c < 8% were assigned to the control group (n=62). Participants of control group were matched by gender and BMI with the case group. Additionally, the insulin resistance was assessed according to validated eGDR (estimated glucose disposal rate) and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) mathematical formulae. HOMA-IR ≥2.5 indicates IR. eGDR <4 mg/kg/min reffer severe IR. Data was analyzed using SPSS 27.0 software. The level of statistical significance was set as P<0.05.

Results: Total of 120 participants were included, data are shown in Table 1.

Conclusions: 1. Subjects with severe insulin resistance had higher daily insulin requirement, HOMA-IR value and lower eGDR. 2. The prevalence of microvascular and macrovascular complications, overall mortality in the groups was similar. 3. Diabetic neuropathy tended to be higher in the Case group.