Endocrine Abstracts

Aim: Determine the state of the kidneys by the concentration of blood creatinine in patients with type 2 diabetes in post-EVRP.

Materials and Methods: Patients with type 2 diabetes who underwent EVRP were included in the 1st stage of the study. 2 groups of patients: in whom CI-AKI developed in the post-procedural period (29 patients) and patients with an uncomplicated course of the post-procedural period (27 patients).

Results: In patients with type 2 diabetes in both groups, the initial creatinine concentration significantly exceeded the CG values (90.41±1.85 µmol/l and 96.89±1.40 µmol/l in the CI-AKI+ and CI-AKI- groups, respectively, versus 55.60±2.53 µmol/l in the CG, the reliability of comparison of both groups of DM with CG was P<0.001). Moreover, in the CI-AKI- group, the creatinine concentration was slightly higher than in the CI-AKI+ group (P<0.05). On the 4th post-procedural day: the relative dynamics in the CI-AKI+ group was 65.06% vs 16.12% in the CI-AKI- group (P<0.001 significance of the difference in the relative dynamics between the groups). Subsequently, the creatinine concentration in both groups decreased, reaching the initial values in the CI-AKI+ group by the 10th day after EVRP, and in the CI-AKI- group, by the 6th day of observation and subsequently decreasing significantly below the initial values, which is probably due to both hydrations after EVRP, and the use of antiplatelet therapy, and lifestyle modification.

Conclusion: During the entire post-procedure period of observation in the CI-AKI- group, the blood creatinine concentration remained significantly lower than in the CI-AKI+ group (P<0.001 - significant intergroup difference on the 4th day).