ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
The effect of olfactory odour stimulation on serum oxytocin levels and glucose metabolism: Data from the OLFAMET study
Lolita Matiashova 1,2 , Anouk Hoogkamer 1 , Alexander Komai 1 , Chery Kunz 1 , Milica Popovic 1 , Yanick Spaar 1 , Elias Zehnder 1 , Judith Minder 1 , Nimmy Varghese 3 , Antje Welge-Lüssen Lemcke 4 , Anne Eckert 2,5 & Katharina Timper 1,6
1University Hospital Basel, Department of Endocrinology, Diabetology and Metabolism, Basel, Switzerland; 2University of Basel, Medical Faculty, Basel, Switzerland; 3University of Basel, Research Platform, Molecular & Cognitive Neuroscience, Division of Neurobiology, Basel, Switzerland; 4University Hospital Basel, Ear, Nose, Throat Clinic, Basel, Switzerland; 5Psychiatric University Clinics Basel, Neurobiology Lab for Brain Aging and Mental Health, Basel, Switzerland; 6University of Basel, Department Biomedicine Basel, Basel, Switzerland
Background: Studies in rodents and non-human primates revealed beneficial effects of oxytocin on systemic metabolism, body weight and food intake. Several rodent studies demonstrated that olfactory stimulation with D-limonene, improves systemic glycemia, reduces food intake and body weight, while olfactory stimulation with the scent of lavender oil had opposite effects. The aim of this study was to investigate if systemic oxytocin levels are affected upon olfactory stimulation with D-limonene and lavender oil, compared to placebo, in obese humans.
Methods: Single-centre, randomized, cross-over trial with n= 40 participants of both genders, age 18-60 years, with a body mass index (BMI) ≥ 35 kg/m2. Only participants with normosmia (as defined by Sniffin’ Sticks Test and threshold, discrimination and identification (TDI) score) and absence of co-morbidities were included. Participants were stimulated with D-limonene, lavender oil and placebo (propylene glycol, all from Sigma Aldrich) for 15 minutes in a randomized cross-over fashion and a wash-out period of 1 week between treatments. After olfactory stimulation, participants received a calorie- and carbohydrate-rich mixed meal test, and blood glucose was measured at 0, 5, 15, 30, 60, 90, 120 minutes. Oxytocin levels were measured via an ELISA kit before and directly after olfactory stimulation with the different odours.
Result: The study included 40 subjects (12 males, 28 females) with a median age of 38.5 [28: 50.5] years and a median BMI of 38.1 [36.2: 42.5] kg/m2. There was no difference in oxytocin plasma levels before and after olfactory stimulation with D-Limonene or lavender oil vs placebo (delta (Δ) for D-limonene -2.23 [-14.84: 13.64] pq/ml (P=0.696), Δ lavender oil 0.35 [-15.33: 16.38] pq/ml (P=0.804) and Δ placebo 2.71 [-8.15: 14.29] pq/ml (P=0.455). Participants were divided into subgroups by BMI (< 40 kg/m2 vs ≥ 40 kg/m2) and further by gender. The only subgroup with an increase in plasma oxytocin were men with a BMI < 40 kg/m2 upon olfactory stimulation with D-limonene (Δ 14.73 [2.45: 34.04] pq/ml (0.036*)), while neither changes were seen upon lavender oil (Δ - 7.24 [- 18.60: 2.28] pq/ml (P=0.093)) or placebo (Δ 3.75 [-10.36: 18.45] pq/ml (P=0.779)) nor in the other subgroups.
Conclusion: Acute olfactory stimulation with D-limonene increases plasma oxytocin levels exclusively in men with BMI < 40 kg/m2. Thus, metabolic effects upon olfactory D-Limonene treatment do not seem to be related to changes in systemic oxytocin.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more