Endocrine Abstracts

Introduction: The effect of aldosterone levels on the severity of arterial hypertension was established in many studies. Changes in the level of aldosterone can lead to disorders of the cardiovascular, nervous, excretory systems. One of the factors affecting the fluctuation of aldosterone is the presence of adrenal gland mass.

Aim: To check for a correlation between the identified adrenal masses and the severity of arterial hypertension against the background of elevated aldosterone.

Materials and Methods: The study included 702 cases with changes in aldosterone levels between 2003-2022. Group 1 included 378 patients without identified formations in the adrenal glands; group 2-324 patients with identified formations. The analysis was carried out according to: gender, the severity of hypertension, the presence/absence of mass in the adrenal glands, the size of the formations.

Results and Discussion: Changes in aldosterone levels are more common in women (75.13% (284), 79.94% (259) in groups 1,2, respectively, compared with men (24.87% (94), 20.06% (65)) in groups 1, 2 respectively), (P<0.05). In group 1, blood pressure was measured in 326 patients, of which: normal 8.28% (27), elevated 23.62% (77), stage 1 25.46% (83), stage 2 42.64% (139); in group 2, BP was measured in 319 patients, of which: normal 7.84% (25), elevated 2.82% (9), stage 1 37.30% (119), stage 2 52.04% (166). Adrenal formation was detected in 46.15% (326) of them in the right 36.20% (118), in the left 50.92% (166), in both 12.88 (42), 53.85% (378) were not detected. In group 2, formations of the right adrenal gland that were less than or equal to 1 cm accounted for 5.08% (6), more than 1 cm 94.92% (112); formations of the left adrenal gland that are less than or equal to 1 cm were 10.84% (18), more than 1 cm 89.52% (148). The change in fluctuations in the level of aldosterone in comparison of the two groups: aldosterone in group 1 is increased by 28.25% (87), normal 70.45% (217), decreased by 1.3% (4). Aldosterone in group 2 increased by 15% (45), normal 84% (252), decreased by 1% (3).

Conclusions: 1. Changes in aldosterone levels are more common in women than men in both groups. 2. In both groups, there is an increase in BP. 3. An increase in BP to stages 1,2 is more common in group 2. 4. Formations in the left adrenal gland are more common. 5. Formations are more often larger than 1 centimeter.