ECE2023 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (355 abstracts)
Influence of diabetes mellitus on changes in preperitoneal fat measured by nutritional ultrasound, in a cohort of patients who required intensive care unit (ICU) admittance due to severe covid-19 pneumonia, during a 6-month follow-up program
Víctor José Simón Frapolli 1 , Isabel Vegas Aguilar 1 , Victoria González Rosa 2 , Ana María Sánchez García 3 , Francisco José Tinahones Madueño 1 & José Manuel García Almeida 1
1Hospital Universitario Virgen de la Victoria, Endocrinology and Nutrition, Málaga, Spain; 2Complejo Hospitalario Universitario Insular Materno Infantil, Endocrinology and Nutrition, Las Palmas de Gran Canaria, Spain; 3Hospital Universitario Virgen de la Victoria, Intensive Care Unit, Málaga, Spain
Introduction and Objectives: Preperitoneal fat is an ectopic visceral adipose tissue with a significant proinflammatory metabolic impact. The objective of this study is to measure preperitoneal fat by nutritional ultrasound at discharge, 3 months and 6 months in a cohort of patients who required admission to the Intensive Care Unit (ICU) due to severe COVID-19 pneumonia, and to analyze the differences based on the presence or not of previous DM.
Material and Method: Complete morphofunctional assessment was performed on 76 patients who were admitted to the ICU due to severe COVID-19 pneumonia, at discharge, 3 months and 6 months. Subsequently, preperitoneal fat measured by nutritional ultrasound was compared between diabetic and non-diabetic patients, using ANOVA for paired data (corrected by the Bonferroni test).
Results: Prospective observational study including 76 patients, 22 diabetics and 54 non-diabetics.
| Baseline | 3 months | 6 months | Global P (a,b,c) | |
| Preperitoneal fat (non-DM) (cm) | 0.856(0.5) | 0.671(0.5) | 0.469(0.3) | 0.011 (0.056,0.092,1.000) |
| Preperitoneal fat (DM) (cm) | 0.503(0.3) | 0.469(0.3) | 0.538(0.4) | 0.859(0.848,0.975,1.000) |
| a=statistical significance baseline-3 months (P<0.05).b=statistical significance baseline-6 months (P<0.05).c=statistical significance 3 months-6 months (P<0.05). | ||||
Conclusion: During follow-up, patients without diabetes present a statistically significant decrease in preperitoneal fat, probably related to the resolution of the intercurrent infection (decrease in CRP during follow-up). In contrast, in diabetic patients it remains constant with no differences during follow-up despite the progressive decrease in CRP, which may be related to the chronic metabolic impact produced by DM.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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