Endocrine Abstracts

Aim: To evaluate the effect of the terminal stage of CKD on the quality of life (Qol) associated with health in patients with DFS.

Material and Methods: 48 patients were examined with DM 2 in the period 2021 -2022. All observed patients were divided into 2 groups: 1 gr. - 23 patients with DFS, complicated by ulcers, gangrene and amputation and combined with CKD 4-5 stages on hemodialysis. 2 gr - 25 patients with DFS, complicated by gangrene and amputation, without CKD. The control group amounted to 20 healthy persons. The patients were performed biochemical (bilirubin, straight, indirect, lipid spectrum, Alt, Ast, Coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, and instrumental: ECG, MRI of foot, etc. The quality of life was evaluated using the international questionnaire a brief form SF-36.

Results: Both groups consisted of patients with an active form of diabetic foot (ulcer, stacker stop, infection) and were comparable by age and sex. It was found that patients with DFS and tsCKD on hemodialysis have significantly higher levels of creatinine, lower levels of hemoglobin, lower levels of albumin, higher performance of peripheral arteries, and lower neuroarthropathy rates of Charcot than in patients with DFS without tsCKD. In patients with DFS with tsCKD on hemodialysis there is a decrease in the quality of life, manifested by low indicators of both physical (by 49.3%) and psychological (by 50.1%) health components. Patients with DFS without tsCKD have a decrease in the of Qol., manifested by low indicators of both physical (by 27.8%) and psychological (by 34.6%) health components

Conclusions: tsCKD negatively affects physical quality of life to a greater extent than mental, in patients with DFS. 2).