ECE2023 Eposter Presentations Calcium and Bone (99 abstracts)
Variations in plasma free 25-hydroxyvitamin D concentrations during intermittent fasting are independently correlated with amino acid intake among meat and non-meat eaters
Spyridon Karras 1 , Theocharis Koufakis 1 , Lilian Adamidou 2 , George Dimakopoulos 3 , Eirini Melidou 1 , Paraskevi Karalazou 4 , Katerina Thisiadou 4 , Pantelis Zebekakis 1 , Kali Makedou 4 & Kalliopi Kotsa 1
1Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Division of Endocrinology and Metabolism, First Department of Internal Medicine, Thessaloniki, Greece; 2AHEPA University Hospital, Department of Dietetics and Nutrition, Thessaloniki, Greece; 3BIOSTATS, Ioannina, Greece; 4AHEPA General Hospital, School of Medicine, Aristotle University of Thessaloniki, Laboratory of Biochemistry, Thessaloniki, Greece
Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.
Methods: Total and free 25(OH)D, parathyroid hormone, VDBP, and anthropometric data were evaluated in 59 Orthodox fasters and 46 controls at three time points: at baseline, 7 weeks after the implementation of diets, and 5 weeks after the participants returned to their typical eating habits (12 weeks from baseline). The intake of amino acids for both diets was evaluated at all time points and possible associations with longitudinal changes in markers of vitamin D homeostasis were explored.
Results: Free 25(OH)D concentrations increased in both groups during the study. At 7 weeks, Orthodox fasters had higher concentrations than controls (9.52±4.97 vs 4.96±2.08 ng/ml, P=0.003). In the OF group, VDBP concentrations increased at 7 weeks compared to baseline values (286.37±86.90 vs 230.11±58.46 μg/ml, P=0.004), followed by a decrease at 12 weeks compared to 7-week measurements (234.66±57.82 vs 286.37±86.90 μg/ml, P=0.032). In contrast, a decrease in VDBP concentrations of controls was observed at 7 weeks compared to baseline (206.94±40.01 vs 277.70±76.01 μg/ml, P=0.008), followed by an increase at 12 weeks compared to 7-week values (290.12±76.28 vs 206.94±40.01 μg/ml, P=0.014). An increase in amino acid intake between baseline and 12 weeks was independently correlated with higher free 25(OH)D values at 12 weeks for both groups.
Conclusion: Our findings suggest that diet composition can affect free 25(OH)D concentrations, through variations in amino acid intake, independently of exposure to sunlight, and provide novel mechanistic insights into the future planning of vitamin D supplementation strategies and food fortification policies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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