ECE2023 Eposter Presentations Late Breaking (91 abstracts)
Does probiotics consumption improve glycemic parameters in adults with obesity?
Rym Ben Othman , Zeineb Zemni , Chaima El Ghali , Wafa Douiri , Berriche Olfa , Ramla Mizouri , Nadia Ben Amor , Faten Mahjoub & Jamoussi Henda
National Institute of Nutrition of Tunis, Obesity Research Unit, Bab Saadoun, Tunis, Tunisia
Introduction: Alteration of gut microbiota leads to increased intestinal permeability, inflammation, and metabolic disorders. The aim of our study was to determine the effect of probiotic supplementation on glycemic parameters in addition to a weight loss program.
Methods: This is an interventional study including 30 obese patients consulting the obesity unit of the Institute of Nutrition in Tunis. The patients were divided into 2 groups matched for age, sex and BMI: diet alone and probiotics (1 tablet of Lactibiane*/day). Glycemic parameters (fasting blood glucose, HbA1c, fasting insulin levels and HOMA index= insulin resistance score) were assessed at T0 and at one month after the intervention (T1).
Results: The mean age was 42.3 ±5.7 years with sex ratio Male/Female =0.25. Diabetes was found in 6.7% of patients in the diet alone group and 13.3% of patients in the probiotic group (the difference between the two groups was not significant P0.3). There was no significant difference between the two groups for glycemic parameters at T0 (fasting blood glucose (FBG), HbA1c, fasting insulin levels and HOMA index). For the diet alone group, there was a significant decrease only in HbA1c between T0 and T1 (P=0.03). For the probiotic group, we found a significant decrease in all glycemic parameters: FBG (P=0.03), HbA1c (P=0.03), insulin levels (P=0.009) and insulin resistance score (P=0.008). A statistically significant difference between the diet alone group and the probiotic group was found only for the decrease in fasting blood glucose (P=0.02).
Conclusion: Probiotics are superior to diet alone in improving the glycemic profile. Thus, they therefore have their place in the therapeutic arsenal of pre-diabetes and diabetes in patients with obesity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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