Endocrine Abstracts

Objective: Subclinical Cushing’s Syndrome is defined as the condition of detecting moderate autonomic cortisol secretion, and it has many conditions such as diabetes, obesity, hypertension, osteoporosis, cardiovascular events, thromboembolic disease, dyslipidemia and immunosuppression comorbidities and with mortality having a relationship shown. Declared a global pandemic COVID-19 infection rapidly spreading with symptoms characterize andmortal one who can watch is a disease. COVID-19 in patients, especially respiratory have a failure in patients steroid in treatment is used in a certain phase when used steroid this treatment in the patient group important to prognosis extent of benefit provides many in the study shown. Subclinical Cushing Syndrome diagnosed patients infected with COVID 19 when, present endogenous cortisol of the height contribution to prognosis completely unknown. Endogenous cortisol height, during treatment applied with cortisol similar effect being or hypercortisolemia caused by immunosuppression status clinical disease your course to worsen are likely to contribute. This The aim of the study endogenous hypercortisolemia condition COVID-19 in patients prognosis whether your contribution that you are not is research.

Materials and Methods: Dokuz Eylul University, Faculty of Medicine, Department of Internal Medicine, Endocrinology in the Department of Science adrenal incidentaloma and Subclinical Cushing Syndrome follow-up and treated, 18 over age, (n=415) of patients biochemical examinations and viewing methods back records facing down examined, the same in time 01.01.2020- 01.10.2222 between COVID-19 testing to the results has been reached. This patientin groups COVID-19 course of illness and mortality rate was compared. Incidentaloma detected patients Subclinical Cushing Syndrome and non-functional adrenal incidentaloma in the form of patients divided into two groups. Sublinic Cushing Syndrome and non-functional incidentaloma diagnosed 1 mg of patients DST result cut off value is accepted as 1.8 µg/dl was done. Both among the group nominal variables that with square test compared. All analyzes SPSS (24.0) with the program done.

Results: In this study, we have done due to adenomas autonomous cortisol secretion there was no significant difference in the frequency of transmission of COVID-19 in patients who were diagnosed with the disease compared to the patients who did not produce hormones. At the same time, a 1 mg DST result of >1.8 µg/dl was not found to be associated with a complicated course in patients with COVID-19 positivity. However, in our study, it was found that the risk of developing complications in the course. of the COVID-19 disease increased 2.17 times in patients with SCS compared to patients with NFA.