Endocrine Abstracts

The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects reduce disease risk and mortality. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. With emergence of –omics technologies, the number of exercise-associated signalling molecules that have been identified has rapidly expanded. Signalling moieties released by skeletal muscle are defined as m...

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Extracellular vesicles (EVs) constitute a novel biological entity to identify biomarkers, and as active players in the development of liver diseases. Omics technologies have been widely applied to characterize the content and function of EVs secreted by liver cells in different pathological scenarios including drug-induced liver injury (DILI), NAFLD and metabolic syndrome. Thus, transcriptomics and proteomics of these EVs have provided several low invasive candidate biomarkers...