Endocrine Abstracts

Since the statistical error in the RDA calculation for vitamin D has been revealed, and verified, concerns have been raised, turning the perpetual vitamin D debate groundless. Daily vitamin D up to 1000 IU <6 m, 1500 6 m-1 yr, 2500 1-3 yrs, 3000 4-8 yrs, 4000 >8 yrs are the IOM’s upper tolerable limits not requiring medical supervision according to the Endocrine Society Practice Guideline Committee. The hazard ratio for all-cause mortality plateaus with 25(OH)D &#...

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Vitamin D deficiency is associated with several adverse skeletal and extra-skeletal outcomes including cancer, cardiovascular diseases, and mortality. Large randomized controlled trials (RCTs) have been conducted over the last few years with the aim to evaluate the cause-and-effect relationship of vitamin D and health outcomes. These RCTs failed to document significant effects of vitamin D on their primary outcome measures, whereas explorative analyses and meta-analyses sugges...