Endocrine Abstracts

Current strategies for identifying substances that adversely affect the thyroid hormone (TH) system (e.g. endocrine disrupting compounds [EDC]) are exclusively focussed on changes in serum TH concentrations and thyroid histopathology. This is based on the assumption that altered TH concentrations in serum directly result in impaired TH action in tissues. However, TH action is also regulated by hormone transport into cells and tissues (e.g. MCT8), activation of T4 to T3 by deio...

Diabetes prevalence has been worryingly growing in recent decades, reaching pandemic proportions. Genetic and environmental factors play a role in diabetes aetiology. While the genetic background may predispose individuals to the disease, environmental factors, including exposure to chemical pollutants that can disrupt metabolic functions (also known as metabolism disrupting chemicals or MDCs), may act as triggers to diabetes development. Despite growing evidence suggesting a ...

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