Endocrine Abstracts

Background: Reproductive health is a state of complete physical, mental, and social well-being. So far, there is limited evidence about the consequences of Sars-CoV-2 infection on women’s reproductive health.Aim: To determine the effects of Sars-CoV-2 infection on women’s reproductive health.Methods: We created an anonymous survey about reproductive health and shared it with women of reproductive age between May 2022 and ...

Background: Many questions concerning polycystic ovary syndrome (PCOS) remain unsolved, such as the long term evolution of cardiovascular (CV) risk markers and the risk for CV events.Methods: A total of 119 PCOS patients diagnosed in 2009 by NIH criteria at our Unit were evaluated at baseline for cardiovascular risk markers (hypertension, diabetes mellitus-DM, dyslipidaemia, obesity, carotid intima media thickness-cIMT, and epicardial fat thickness-EFT) ...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. Using ESHRE/ASRM diagnosis of PCOS is considered when 2 of 3 criteria are present: polycystic ovary morphology (PCOM), oligo/anovulation (ANOV) and hyperandrogenism (HA). These criteria form four different phenotypes: A (ANOV, HA, PCOM), B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM). Several studies have found differences in anthropometric, hormonal and meta...

Background: The reserve pool of primordial follicles (PMF) is finely regulated by molecules implicated in follicular growth or PMF survival. Anti-Müllerian Hormone (AMH), produced by granulosa cells of growing follicles, is known for its inhibitory role in the initiation of PMF growth. We observed in a recent in vivo study that injection of AMH into mice seemed to induce an activation of autophagy, a cytoplasmic lysosomal-dependent degradation system, which is im...

Heterozygotes carrying CYP21A2 gene mutations are found in 5-10% of the general population in Mediterranean countries. Accumulating data suggest a survival advantage of this population, despite the fact that carriers of two mutations suffer from either classical or non-classical congenital adrenal hyperplasia (NC-CAH), an entity with increased mortality. In an attempt to elaborate on this issue we evaluated females of reproductive age with CYP21A2 heterozygocity (HET). We have...

Background: Low bone mineral density (BMD) and reduced sexual satisfaction have been reported in complete androgen insensitivity syndrome (CAIS). Nevertheless, conclusive data on the prevalence and on the optimal management of these conditions are still lacking.Aims: To assess bone and sexual health in adult women with CAIS with and without gonadectomy.Methods: Single-centre, prospective study of 27 adult CAIS (age 35.2±8.7 ye...