Rapid Communications 2: Thyroid

Background: Vaccination is a widely adopted measure against the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) causing Covid-19 pandemic. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Graves orbitopathy (GO) following Covid-19 vaccination.Methods: The study included 98 consecutive patients (71 females and 27 males, mean-age 50 years) attending our tertiary r...

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ea0090rc2.2 | Rapid Communications 2: Thyroid | ECE2023

Overtreatment of differentiated thyroid cancer: impact on real world clinical practice of conservative guidelines, as recorded by the Italian Thyroid Cancer Observatory Study

Grani Giorgio , D'Elia Silvia

Background: The incidence of differentiated thyroid cancers is increasing, mainly due to the overdiagnosis of small papillary thyroid cancers (less than 1 cm, previously known as microcarcinomas). There is a broad consensus in reducing the surgery extent and the use of radioiodine treatment in low-risk cases by most recent clinical practice guidelines focusing on thyroid cancer treatment. The adoption in real clinical practice is usually slow. The aim of this study is to estim...

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ea0090rc2.3 | Rapid Communications 2: Thyroid | ECE2023

A simplified four-tier classification of thyroid core needle biopsies (CNB) is an efficient system. Evidence based on more than 1,000 surgical cases

Paja Fano Miguel , Zabala Rosa , Korta Igone , Delgado Sandra , Luis Del Cura Jose , Rodriguez-Soto Josune , Izquierdo Jon , Garai Jon , Oleaga Amelia , Teresa Gutierrez M. , Exposito Amaia , Zufiaurre Maite , Ugalde Aitziber

CNB is increasingly being used as a diagnostic test for thyroid nodules with an inadequate (Bethesda 1) or indeterminate (Bethesda 3 and 4) FNAC results, which can account for up to 30% of the samples in some studies. CNB, using larger specimens and histological sections rather than cytological samples, allows better definition. We propose a simplified four-tiered classification of CNB specimens instead of the Bethesda system and evaluate its efficiency compared to definitive ...

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ea0090rc2.4 | Rapid Communications 2: Thyroid | ECE2023

Cell free DNA Integrity index to differentiate benign from malignant thyroid nodules

Tarafdar Soham , Dutta Susmita , P. Bhattacharyya Nitai , Mukhopadhyay Pradip , Ghosh Sujoy

Introduction: Cell-free DNA (cfDNA) integrity in plasma has been investigated as a non-invasive marker in cancer. Thyroid cancer the most common endocrine malignancy sometimes presents as indeterminate nodules and difficult to diagnose without histopathology.Aim of the study: The present study aims to test the hypothesis that the presence of longer DNA strands circulating in plasma can be considered a marker for thyroid cancer.Meth...

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ea0090rc2.5 | Rapid Communications 2: Thyroid | ECE2023

Lack of GPER-TSHR heteromers is a hallmark of thyroid cancer

Perri Carmela , D'Alessandro Sara , Paradiso Elia , Lazzaretti Clara , Mascolo Elisa , Baschieri Lara , Roy Neena , Sperduti Samantha , Simoni Manuela , Brigante Giulia , Casarini Livio

Thyroid cancer is the most common type of endocrine tumor and reaches the peak of incidence between the age of twenty and fifty years. It has 4-fold higher prevalence in females than males, suggesting that estrogens and their receptors could be involved in thyroid cancer pathogenesis. Previous studies demonstrated allosteric interference operated by G protein-coupled estrogen receptor (GPER) to molecules structurally similar to the thyroid-stimulating hormone (TSH) receptor (T...

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ea0090rc2.6 | Rapid Communications 2: Thyroid | ECE2023

Abstract withdrawn...

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Endocrine Abstracts

25th European Congress of Endocrinology