ECE2023 Rapid Communications Rapid Communications 11: Late Breaking (6 abstracts)
Immune checkpoint inhibitors and severe insulinopenic diabetes mellitus: A single center experience
Ruti Karov 1 , Roy Eldor 1 , Tamara Kolitz 1 , Michal Ehrenwald 1 , Eugene Feigin 1 & Yona Greenman 1
1Tel Aviv-Souraski Medical Center, Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Yafo, Israel
Introduction: Severe insulinopenic diabetes (SID) is a rare complication of treatment with immune checkpoint inhibitors (ICPI). We describe herein the clinical characteristics, natural history and potential predictors of SID in cancer patients treated with ICPI.
Methods: We identified and retrospectively retrieved pertinent clinical data of all patients who presented with new onset SID following treatment with ICPI between 2015 and 2022 at the Tel Aviv-Sourasky Medical Center.
Results: The study cohort comprised 1621 ICPI-trated patients, of whom 12 patients (0.8%) developed SID. Seven were males (53.8%). Median age was 67 (IQR 60.5-77) years. Eight patients (61.5%) were treated with PD-L1 inhibitors, 3 (23.1%) with PD-1 inhibitors and 2 (15.4%) with a combination of PD1 and CTLA4 inhibitors . Two patients had a prior diagnosis of type 2 diabetes treated with oral medications while 2 other patients had a prior diagnosis of impaired fasting glucose. Three patients (23.1%) developed a concomitant thyroid dysfunction under ICPI. Median time from the initiation of ICPI to presentation of SID was 4 months (IQR 1-9). Five of the patients presented with SID within a month from exposure (38.5%). DKA was the presenting symptom in eleven patients (84.6%), 3 of which were treated with a SGLT2i . One patient (7.7%) died within one week of DKA presentation.
Conclusions: This is one of the largest single center series describing the onset and characteristics of SID following ICPI treatment.
Volume 90
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more