Endocrine Abstracts

Introduction: The incidence of papillary thyroid cancer (PTC) in the coexistence of Graves’ disease (GD) and thyroid nodule is not known clearly, and the pathophysiology of PTC development in these patients is still unclear.

Aim: The aim of our study is to compare the clinicopathological features of GD patients with thyroid nodule + PTC and patients with euthyroid and non auto-immune thyroid nodule + PTC and investigate the clinicopathological features’ of the patients.

Material and Method: Preoperative and postoperative clinicopathological features of 239 patients diagnosed with PTC between 2000 and 2021 were evaluated retrospectively. The patients were evaluated in 2 groups as GD+PTC and only PTC.

Results: There were 99 patients in the group with GD+PTC and 140 patients in the group with PTC without GD. The female gender was higher in the GD+PTC group. Tumor diameter was smaller in the GD+PTC group (1,45±1,28 cm vs 1,81±1,34 cm). Multifocal involvement was significantly less in the GD+PTC group compared to the PTC group. Among the histopathological subtypes of PTC, follicular subtype was more common in patients with non-GD PTC. Frequency of tall cell subtype was similar between two groups.

Conclusion: Malign thyroid nodules’ ultrasonographic features are not different in patient with GD and PTC. In addition, presence of less multifocality and smaller tumor size in papillary carcinoma patients with Graves’ disease may be considered a favorable feature.