Endocrine Abstracts

Introduction: The malignancy of the thyroglossal duct cyst is infrequent, 0.7 to 1% of the thyroglossal duct cysts, predominantly in women and euthyroid subjects, some associated with Hashimoto’s Thyroiditis.

Clinical case: Male, 42 years old, with a 5-year history of a large anterior cervical tumor, diagnosed with Graves’ disease and thyroid orbitopathy. Cervical ultrasound reports right submandibular region mixed tumor mass 36 x30. mm with nonspecific lateral cervical lymph nodes and multiple mixed oval images, well-defined borders, less than 13 mm in diameter. The ophthalmological evaluation reports moderate quiescent orbitopathy. He received treatment with high doses of methimazole and lithium carbonate for severe hyperthyroidism with difficult stabilization. Sistrunk surgery and total thyroidectomy was performed. Histology reports papillary thyroid carcinoma on a thyroglossal duct cyst, 1, 5 cm, without evidence of thyroid neoplasia.

Discussion: In the literature reviewed, no association was reported with primary papillary thyroid carcinoma in a thyroglossal cyst and Graves’ disease. Due to the low frequency of papillary thyroid carcinoma in the thyroglossal duct, a single algorithm has not been reached for its treatment and follow-up, it must be approached by a multidisciplinary team based on the current guidelines for differentiated thyroid cancer, which coincide that Sitrunk surgery and total thyroidectomy is the most appropriate initial treatment.