ECE2023 Poster Presentations Thyroid (163 abstracts)
Lower expression of miR-21 is related to multifocal lesions of papillary thyroid carcinoma
Aistė Kondrotienė 1 , Albertas Daukša 2 , Diana Pamedytyte 3 , Mintautė Kazlauskienė 1 , Aurelija Žvirblienė 3 , Dalia Daukšienė 1 , Vaida Simanavičienė 3 , Raimonda Klimaitė 1 , Valdas Šarauskas 4 , Rasa Verkauskienė 1 & Birutė Žilaitienė 1
1Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Institute of Digestive Research, Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania; 4Department of Pathology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Introduction: Multifocality empirically is often treated as a risk factor for aggressive course of papillary thyroid carcinoma (PTC), encouraging aggressive treatments. However, inconsistency and even contradiction in a literature is present concerning the role of tumor multifocality in clinical outcomes of PTC. Therefore, the prognostic value of multifocality of PTC remains controversial, creating a difficulty in the current clinical management.
Methods.: We analyzed miR-146b, miR-21, miR-221, miR-21, and miR-181b in formalin fixed paraffin embedded PTC tissue samples of 312 individuals and evaluated their expression relationship with multifocality of a tumor.
Results.: Multifocality was observed in 68 (21,7%) of the PTC patients. Patients with multifocal lesions had significantly lower expression of miR-21 than those with unifocal (n=224) lesions (P<0.011) in our study. MiR-146b, -221, -222, 181b expression did not statistically significantly differ between these groups.
Conclusions: Our results suggest that lower expression of miR-21 is related to multifocal lesions. Data from numerous other studies confirm that miR-21 is usually overexpressed in PTC associated with aggressive clinicopathological features. So, our findings of lower miR-21 expression let us to hypothesize, that multifocality might not be a risk factor of poor PTC prognosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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