Endocrine Abstracts

Objective: To explore the association between body mass index (BMI) and plasma glucose level with pathological features and clinical outcomes of differentiated thyroid cancer (DTC).

Methods: Clinical data of 1264 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of the first ¹³¹I treatment from April 2016 to July 2020. The clinicopathological findings were compared in the groups were categorized according to BMI and glycemic disorders. Independent samples t-test, Mann-Whitney U test and χ²test were employed to compare the correlation between BMI and plasma glucose level with pathological features and response evaluation of DTC. Logistic regression analysis was used to analyze the independent risk factors for the aggressiveness of DTC.

Results: The analysis according to BMI evidenced overweight and obesity were more frequent in males (P=0.000) while patients in the overweight group were older and had higher TNM stage (P=0.000, 0.004). The proportion of patients with bilateral tumors was higher in the overweight and obese group (P=0.001). However, there was no significant correlation between BMI and lymph node metastasis, TNM stage, T stage, N stage, M stage and response evaluation (P> 0.05). Diabetes group are older than the other groups, and the proportion of men and bilateral tumors were found to be significantly higher (P=0.000, 0.000, 0.045). Compared with the normal blood glucose group, the BMI index of patients with prediabetes and diabetes is higher, and the BMI index of patients with prediabetes is the highest (P=0.000). The T stage and TNM stage were higher in the diabetes group (P=0.032, 0.000). However, there was no significant correlation between glycemic status and lymph node metastasis, N stage, M stage and response evaluation (P> 0.05).

Conclusions: DTC patients with high BMI and diabetes may have more aggressive incidence. But BMI and glycemic status has no correlation with the response evaluation of DTC patients.

Keywords: Differentiated thyroid carcinoma; Body mass index; Glycemic status; Obesity