Endocrine Abstracts

Relevance: PCOS is a multifactorial heterogeneous disease associated with endocrine, reproductive, and metabolic manifestations. The relevance of the PCOS problem is determined by its high prevalence worldwide among women of childbearing age (5 - 20%). It is worth noting that the main reproductive signs of PCOS appear in late prepubertal and pubertal periods. The aim is to carry out a comparative analysis of hormonal indicators in PCOS

Materials and Methods: A total of 120 adolescent girls aged 14-18 years, diagnosed with polycystic ovarian syndrome, were included in the study. Hormone balance was determined using a «PW 300 M Chemistry Analizator» (USA). The results obtained were statistically processed by determining the mean mathematical limit (m), standard deviation, mean error of mathematical limit (m). The results were considered statistically significant at P<0.05. Statistical studies were performed using Microsoft Excel and Statistica 10.0 software.

Results of discussion: The most typical manifestations of PCOS that appeared from the age of menarche were: menstrual cycle (86%), mostly by the type of oligomenorrhea (52%); hirsutism (81.2%). Hormonal analysis revealed a wide variability in FSH in adolescent girls from 3.4 to 64.3 IU/l, and from 2.8 to 7.2 IU/l in the control group, which is associated primarily with insufficient hormonal function of the ovaries. The analysis of the LH content revealed rather high LH values in the blood serum of adolescent girls (13.3+1.6 IU/l). The LH/FSH ratio was 2.3+0.4 (normal-. Thus, changes in the gonadotropin indices are already a precursor of functional disorders of the hypothalamic-pituitary system of menstrual function regulation. In patients with polycystic ovary syndrome individual values of testosterone ranged from 1.8-3.9 (mean 3.1+1.2 nmol/l). The serum AMH content in LPS patients ranged from 2.4 ng/ml to 18.0 ng/ml and averaged 7.6±0.8 ng/ml, which was significantly (P<0.001) higher than its content in healthy women (2.5±1.3 ng/ml). The volume of each ovary ranged from 11.3 to 16.0 cm3 and was larger than that in women without PCOS. The mean number of antral follicles in the ovary was 8.8 ± 1.0 (11 to 12), which was also greater than in women without PCOS.

Conclusions: In PCOS, there is an imbalance between the amount of androgens, antimullerian hormone (AMH), LH and FSH, which results in the failure to select the ‘dominant’ follicle despite relatively rapid and early follicle growth.