ECE2023 Poster Presentations Pituitary and Neuroendocrinology (123 abstracts)
Acromegaly management in the Scandinavian countries – a DELPHI consensus survey
Mai C. Arlien-Søborg 1 , Jakob Dal 2 , Ansgar Heck 3 , Kirstine Stochholm 1 , Eigil H Nielsen 2 , Claus Feltoft 4 , Æse Krogh Rasmussen 5 , Ulla Feldt-Rasmussen 5 , Mikkel Andreassen 5 , Marianne Klose 5 , Torben Leo Nielsen 6 , Marianne Andersen 6 , Louise Lehmann Christensen 6 , Jesper Krogh 5 , Anne Jarlov 5 , Stine Lyngvi Fougner 7 , Ingrid Nermoen 8 , Jens Bollerslev 3 , Marianne Oksnes 9 , Per Dahlqvist 10 , Tommy Olsson 10 , Katarina Berinder 11 , Charlotte Höybye 11 , Maria Petersson 11 , Anna-Karin Ækerman 12 , Jeanette Wahlberg 12 , Bertil Ekman 13 , Britt Eden Engstrom 14 , Gudmundur Johannsson 15 , Oskar Ragnarsson 15 , Helga Ágústa Sigurjónsdóttir 16 , Pia Burman 17 & Jens Otto Jørgensen 1
1Aarhus University Hospital, Department of Endocrinology and Internal Medicine, Aarhus, Denmark; 2Aalborg University Hospital South, Aalborg, Denmark; 3Oslo Universitetssykehus HF, Rikshospitalet, Norway; 4Gentofte Hospital, Hellerup, Denmark; 5Rigshospitalet, København, Denmark; 6Odense University Hospital, Odense, Denmark; 7St. Olav’s University Hospital, Norway; 8Akershus University Hospital, Norway; 9Haukeland University Hospital / Health Bergen, Norway; 10University Hospital of Umeå, Sweden; 11Karolinska University Hospital, Sweden; 12Örebro University Hospital, Sweden; 13Linköping University Hospital, Sweden; 14Uppsala University Hospital, Sweden; 15Sahlgrenska University Hospital, Sweden; 16Landspitali University Hospital, Reykjavík, Iceland; 17Skåne University Hospital Lund - Children Emergency, Sweden
Background: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Guidelines regarding treatment algorithms and follow-up vary considerably.
Aim: To evaluate consensus on the treatment and follow-up of acromegaly in the Scandinavian countries.
Methods: To map the landscape of acromegaly management in the Scandinavian countries, a Delphi process was used. An expert panel developed 37 statements on the treatment and follow-up of acromegaly. Dedicated endocrinologists (n=35) from the Scandinavian countries were invited to participate in three Delphi rounds and rate their extent of agreement with statements concerning management of acromegaly, using a Likert-type scale (1-7). Consensus was defined as ≥ 80% of panelists rating their agreement as 5–7 on the Likert-type scale.
Results: 33 endocrinologists (94 %) answered the survey (55 % women; mean 19 years of experience). Consensus was achieved for 16 (43%) statements distributed as follows: Primary treatment 2/4 (50%), preoperative treatment with Somatostatin analogues 0/4 (0%), second- and third-line treatment 7/19 (36%), treatment in relation to pregnancy 5/7 (71%), long-term follow-up after disease control 2/4 (50%).
Conclusion: This work reflects the clinical perspective of expert endocrinologist from the Scandinavian countries. In >50 % of the statements, consensus was not reached, which may reflect the complexity of the disease and its management, and/or a shortage of evidence-based data.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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