ECE2023 Poster Presentations Environmental Endocrinology (5 abstracts)
Thyroid cancer diagnostics related to occupational and environmental risk factors: an integrated risk assessment approach
Cozma Andreea 1 , Socaciu Andreea-Iulia 2 , Socaciu Mihai Adrian 3 , Petre Gabriel Emil 4 , Berinde Gabriela Maria 5 , Rajnoveanu Armand Gabriel 5 & Piciu Doina 6
1Medisyn Medical Clinic, Endocrinology, Cluj-Napoca, Romania; 2“Iuliu Hatieganu” University of Medicine and Pharmacy, Occupational Health, Cluj-Napoca, Romania; 3“Iuliu Hatieganu” University of Medicine and Pharmacy, Radiology and Imaging, Cluj-Napoca, Romania; 4“Iuliu Hatieganu” University of Medicine and Pharmacy, Surgery, Cluj-Napoca, Romania; 2“Iuliu Hatieganu” University of Medicine and Pharmacy, Occupational Health, Cluj-Napoca, Romania; 6“Iuliu Hatieganu” University of Medicine and Pharmacy, Doctoral School, Cluj-Napoca, Romania
There are still many questions remaining about the etiopathogenesis of thyroid cancer, themost common type of endocrine neoplasia. Numerous occupational and environmental exposureshave been shown to represent important risk factors that increase its incidence. Updated informationabout thyroid cancer diagnostics related to occupational and environmental risk factors is reviewedhere, considering an integrated risk assessment approach; new data concerning thyroid canceretiology and pathogenesis mechanisms, diagnostic biomarkers and methodologies, and risk factorsinvolved in its pathogenesis are presented. A special emphasis is dedicated to specific occupationalrisk factors and to the association between environmental risk agents and thyroid cancer development. The occupational environment is taken into consideration, i.e., the current workplace and previousjobs, as well as data regarding risk factors, e.g., age, gender, family history, lifestyle, use of chemicals, or radiation exposure outside the workplace. Finally, an integrative approach is presented, underlyingthe need for an accurate Risk Assessment Matrix based on a systematic questionnaire. We proposea complex experimental design that contains different inclusion and exclusion criteria for patientgroups, detailed working protocols for achieving coherent and sustainable, well-defined researchstages from sample collection to the identification of biomarkers, with correlations between specificoncometabolites integrated into the Risk Assessment Matrix.
Keywords: Thyroid cancer diagnosis; occupational risk; environmental risk factors; oncometabolites; risk assessment matrix
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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