Endocrine Abstracts

Introduction: During these last years, Intermittent fasting was emerging as an approach that improves weight and metabolic outcomes in obese subjects.

Objective: To investigate the effects of 16:8 intermittent fasting on metabolic and inflammatory parameters in adult obese.

Methods: This is a comparative interventional study conducted in 60 obese women consulting the obesity unit of the Institute of Nutrition of Tunis during the period ranging from May to August 2022. The patients were divided into 2 groups matched for age and sex. G1: standard hypocaloric diet and G2: intermittent fasting 16:8. Anthropometric measurements and biological parameters were taken at T0 and T1 (3 months after the dietary intervention).

Results: The mean age was 35.81±8.92 years. Decreases in weight (P=0.005) and Waist circumference (P<10-3) were significantly greater in patients on the 16:8 IF compared with those on the standard hypocaloric diet. Patients who adhered to intermittent fasting had a greater decrease in fasting blood glucose with a significant difference between the two groups (P= 0.003), HbA1c (P= 0.006), insulin levels (P= 0.003), insulin resistance (P<10-3), uric acid (P= 0.010) compared to patients in the hypocaloric diet group. The variation in lipid parameters was not significant between the two groups. Except for a statistically significant increase in HDL-c in group 2 (P= 0.001). The variation in IL-6 concentration was +0.06 and -0.26 pg/ml respectively for the low-calorie diet group and the intermittent fasting group with P=0.007. No significant variation in TNFα levels was observed afterthe two type of diets.

Conclusion: The results of this study suggest that intermittent fasting is a feasible and effective acceptable dietary model for the management of obese women.