ECE2023 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (159 abstracts)
Serum Vitamin B12 Levels and Diabetic Retinopathy in Type 2 Diabetes
Meriem Adel 1 , Manel Jemel 1 , Radhouen Gharbi 1 , Anis Grassa 1 , Yasmine Chaari 2 , Hajer Kandara 1 , Ines Kammoun 1 , Rahma Mahjoub 2 & Emna Talbi 2
1Nutrition, Endocrinology, Tunis, Tunisia; 2Nutrition, Biochemistry, Tunis, Tunisia
Introduction: Diabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes and the leading cause of blindness worldwide. Several studies have reported the association between metformine-induced vitamin B12 deficiency in type 2 diabetic patients. However, the association between vitamin B12 and DR has only been investigated in few studies.
Materials and methods: A cross-sectional study was carried out on 123 type 2 diabetic patients treated with metformin. One hundred and four patients had a fundus examination: sixty eight patients with DR, 36 patients without DR. Vitamin B12 levels were measured in all participants.
Results: The mean age of the subjects (DR+) was 61.34±6.62 years vs 60.61±6.79 years in patients (DR-). In the patients (DR+) 30.9% were male vs 33.3% (DR). The mean duration of diabetes was 17.72 ±4.1 years in (DR+) and 13.92 ±7.57 years in (DR-) with a significant difference (P=0.01). The mean FBG was 12.53 ± 4.53 mmol/l and 10.58 mmol/l ± 4.53 mmol/l respectively with significant difference (P=0.039). However, there was no difference in mean HbA1c between the 2 groups. Blood levels of vitamin B12 were comparable between patients (DR+) (360.76 ± 165.12) and (DR-) (350.26 ± 219.20). There was no correlation between cobalamin levels and retinopathy (P=0.78). Mean metformin dose was 1908.82 ±606.79 in patients (DR+) and 1984.72±538.36 in patients (DR-). There was no correlation between metformin dose and DR P=0.5. The mean folate level was 7.82±3.19 in patients (RD+) and 8.41±4.25 in patients (DR-). There was no correlation between folate levels and retinopathy.
Conclusion: This study shows that vitamin B12 deficiency does not seem to play a role in DR. Further studies are needed to assess the real impact of vitamin B12 deficiency on DR and to evaluate the Impact of supplementation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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