Endocrine Abstracts

Introduction: Polycystic ovary syndrome is complex endocrine disorders, characterized by ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. Those are lipid abnormalities, hyperinsulinemia, insulin resistance, impaired glucose metabolism, type 2 diabetes mellitus, metabolic syndrome, hyperandrogenism, oxidative stress and infertility. The visceral adiposity index (VAI) is a reliable marker of adipose tissue abnormalities in women with PCOS. A body shape index (ABSI), body adiposity index (BAI) are the other anthropometric indices which have shown correlation with cardiovascular diseases risk and metabolic syndrome risk such as glucose metabolism abnormalities and obesity.

Aim: The aim of this study was to investigate the usefulness of new anthropometric indices such as BAI, VAI, LAP, BRI, ABSI and new atherogenic indices such as TyG index, TyG-BMI index, TyG-WC index in evaluation of glucose parameters in patients with PCOS.

Material and methods: To the study was enrolled of 49 woman with diagnosed PCOS based on the Rotterdam criteria from 2003. Blood samples were taken from patients in the morning, before breakfast. Biochemical parameters (fasting glucose and fasting insulin, glucose and insulin after 60 and 120 minute OGTT, HbA1c, HOMA-IR index) were determined. Anthropometric parameters were measured with the use of standard methods in the morning. These measurements included body weight, height, waist circumference, and hip circumference. After this step anthropometric indices such as BAI (Body Adiposity Index), VAI (Visceral Adiposity Index), LAP (Lipid Accumulation Product), BRI (Body Roundness Index), ABSI (A Body Shape Index), AIP (Atherogenic Risk of Plasma) were calculated. The study conformed to the Declaration of Helsinki and was reviewed by the local bioethics committee

Results: There was observed positive correlation between fasting glucose and analyzed parameters: BAI, VAI, LAP, BRI, TyG index, TyG-BMI index, TyG-WC index (P<0.05). There was reported significant positive relationship between glucose after 60 minutes and VAI, LAP, BRI, ABSI, TyG index, TyG-BMI index, TyG-WC index (P<0.05). There was observed positive correlation between glucose after 120 minutes and VAI, LAP, BRI, TyG index, TyG-BMI index, TyG-WC index (P<0.05). HOMA-IR index was strongly correlated among group of women to all analyzed anthropometric parameters and atherogenic indices (P<0.05).

Conclusion: Analyzed newanthropometric indices and new atherogenic indices have demonstrated significant relationship with glucose profile in women with PCOS. These indices may be useful tool in assessing of metabolic disorders in women with PCOS.