ECE2023 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (159 abstracts)
Vitamin B12, lipid profile and peripheral diabetic neuropathy in type 2 diabetic patients on Metformin: any association?
Meriem Adel 1 , Manel Jemel 1 , Radhouen Gharbi 1 , Asma Kardi 1 , Brahim Khalfa 2 , Hajer Kandara 1 , Ines Kammoun 1 , Rahma Mahjoub 2 & Emna Talbi 2
1Nutrition, Endocrinology, Tunis, Tunisia; 2Nutrition, Biochemistry, Tunis, Tunisia
Introduction: Several studies have evaluated the prevalence and impact of metformin induced vitamin B12 deficiency in type 2 diabetes patients. On the other hand, low vit B12 was associated with adverse lipid profile.
Aim: To evaluate the relationship between vitamin B12 deficiency and the lipid profile in patients with neuropathy.
Patients and methods: A cross-sectional study included 123 type 2 diabetic patients treated with metformin. The presence of distal symmetrical polyneuropathy (DSPN) was determined by Toronto Clinical Neuropathy Score (TCSS). Vitamin B12 levels and lipid profile were measured for all participants.
Results: The mean age of participants was 60.99 ± 6.85 years. About 70% were female. The mean duration of metformin use was 14.6±7.27 years with a mean dose of 1923±575.4 mg/day. The mean total cholesterol level was 4.68 mmol/l ±1.2 mmol/l. The mean triglyceride level was 7.71 mmol/l ±0.96. The mean HDL cholesterol level was 1.11mmol/l ± 0.2 mmol/l and the mean LDL cholesterol level was 1.07 mmol/±0.41. There was a difference between the two sexe in the lipid profile (P<0.005). Eighty three and a half percent of patients were on statins. The mean dose was 24.13 mg/day with extremes ranging from 10 to 80 mg/day. The mean serum Vitamin B12 level was 353.77 ± 178.22 pg/ml with extremes ranging from 64.47 to 918.4 pg/ml. Eighteen and a half percent of the population had a vitamin B12 deficiency (level <200 pg/ml). There was no correlation between vitamin B12 level and lipid profile. Fifty seven percent of patients have mild neuropathy, 23.5% moderate neuropathy and 19.5% severe neuropathy. There was no correlation between TCSS and Lipid profile. There was no correlation between TCSS and statin dose (P=0.79). The mean dose of statins was 23.82 ± 16.75 mg/ day in patients with mild neuropathy,23.10 ± 18.72 mg/day in patients with mild neuropathy and 26.25 ±18.13 mg/day in patients with severe neuropathy.
Conclusion: This study shows no correlation of lipid profile and vitamin B12 level. Statin dose was not associated with the severity of DSPN. Larger studies are needed to clarify the relationship between vitamin B12 and lipid profile.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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